Microbial β-lactone natural products

Microbial β‐lactone natural products

Microbial b-lactone natural products An annotated selection of World Wide Web sites relevant to the topics in microbial biotechnology. Obafluorin is an antimicrobial b-lactone compound produced by the bacterium Pseudomonas fluorescens. In this study, the compound was synthesized, analysed chemically and tested for biological activity. The triedimycins are a class of spiro b-lactones. They are n...

marine microbial natural products

Marine Microbial Natural Products

Copyright © 2014, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences; Published by DOCS. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work ...

Remodeling Natural Products: Chemistry and Serine Hydrolase Activity of a Rocaglate-Derived β-Lactone

Flavaglines are a class of natural products with potent insecticidal and anticancer activities. β-Lactones are a privileged structural motif found in both therapeutic agents and chemical probes. Herein, we report the synthesis, unexpected light-driven di-epimerization, and activity-based protein profiling of a novel rocaglate-derived β-lactone. In addition to in vitro inhibition of the serine h...

Natural products: Hunting microbial metabolites.